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CHECKMATE 214: Overall survival in responders

36

CheckMate 214

NE, not estimable; NR, not reached

Months

0

6

No. at risk

NIVO+IPI

178 177 176 174 173 170 166160 154 144 137 111 49 14 2 0

SUN

124 124 123 122 120 115 112105 100 92 82 67 38 16 1 0

12 18 24 30

1.0

0.8

0.9

0.7

0.6

0.5

0.4

0.3

0.2

0.1

0.0

36 42

3

9 15 21 27 33

45

39

Overall survival (probability)

Months

0

6

No. at risk

NIVO+IPI

49 49 49 48 48 48 46 46 46 46 44 44 37 12 1 0

SUN

62 62 62 62 62 61 60 60 60 60 56 53 42 20 0 0

12 18 24 30

1.0

0.8

0.9

0.7

0.6

0.5

0.4

0.3

0.2

0.1

0.0

36 42

3

9 15 21 27 33

45

39

Overall survival (probability)

(N = 178)

(N = 124)

NIVO+IPI

(N = 62)

NIVO+IPI

NIVO+IPI

SUN

SUN

Intermediate/Poor-Risk Complete/Partial Responders

Favorable-Risk Complete/Partial Responders

88%

82%

98%

96%

NIVO+IPI

(N = 178)

SUN

(N = 124)

Events, n (%)

40 (22.5) 39 (31.5)

OS, median

(95% CI),

months

NR (NE–

NE)

NR (NE–

NE)

NIVO+IPI

(N = 49)

SUN

(N = 62)

Events, n (%)

5 (10.2)

6 (9.7)

OS, median

(95% CI),

months

NR (NE–

NE)

NR (NE–

NE)