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CHECKMATE 214: Overall survival in responders
36
•
CheckMate 214
NE, not estimable; NR, not reached
Months
0
6
No. at risk
NIVO+IPI
178 177 176 174 173 170 166160 154 144 137 111 49 14 2 0
SUN
124 124 123 122 120 115 112105 100 92 82 67 38 16 1 0
12 18 24 30
1.0
0.8
0.9
0.7
0.6
0.5
0.4
0.3
0.2
0.1
0.0
36 42
3
9 15 21 27 33
45
39
Overall survival (probability)
Months
0
6
No. at risk
NIVO+IPI
49 49 49 48 48 48 46 46 46 46 44 44 37 12 1 0
SUN
62 62 62 62 62 61 60 60 60 60 56 53 42 20 0 0
12 18 24 30
1.0
0.8
0.9
0.7
0.6
0.5
0.4
0.3
0.2
0.1
0.0
36 42
3
9 15 21 27 33
45
39
Overall survival (probability)
(N = 178)
(N = 124)
NIVO+IPI
(N = 62)
NIVO+IPI
NIVO+IPI
SUN
SUN
Intermediate/Poor-Risk Complete/Partial Responders
Favorable-Risk Complete/Partial Responders
88%
82%
98%
96%
NIVO+IPI
(N = 178)
SUN
(N = 124)
Events, n (%)
40 (22.5) 39 (31.5)
OS, median
(95% CI),
months
NR (NE–
NE)
NR (NE–
NE)
NIVO+IPI
(N = 49)
SUN
(N = 62)
Events, n (%)
5 (10.2)
6 (9.7)
OS, median
(95% CI),
months
NR (NE–
NE)
NR (NE–
NE)