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Timely start of systemic therapy

• Watchful Waiting vs Active Surveillance

Adapted from Tuttle RM, et al. Best Pract Res Clin Endocrinol Metab. 2017;31(3):295-305.

High Speed

High Burden

Moderate Speed

High Burden

Moderate Speed

Moderate Burden

Low Speed

Low Burden

Stable and

Low Burden