Lenvatinib en el tratamiento sistémico de primera línea en Cáncer Diferenciado de Tiroides Refractario a Radioyodo

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§ INITIAL TREATMENT
§ Total thyroidectomy +/- lymphadenectomy, except in unifocal microcarcinoma
(individualized to patient)
§ ADJUVANT TREATMENT
§ Radioactive iodine ( 131I) (RAI) therapy
§ FOLLOW-UP TREATMENT
§ Levothyroxine to suppress TSH to <0.1 mU/L
§ RECURRENT OR METASTATIC DISEASE TREATMENT
§ Local therapy (re-operation, external radiation)
§ Systemic therapy
Ø RAI therapy
Ø Patients with refractory advanced disease
ü Chemotherapy (limited efficacy and considerable toxicity)
ü Targeted agents or clinical trials
Haugen BR, et al. Thyroid 2017
Management of Differentiated
Thyroid Cancer (DTC)