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Retrospective analysis of M1 STAMPEDE data according to
high/low risk stratification from LATITUDE and CHAARTED:
OS
Overall
OS (HR)
p value
STAMPEDE M1 cohort
0.61
(0.49, 0.79)
<0.001
Low
OS (HR)
p value
STAMPEDE low risk
0.66
(0.44, 0.98)
0.041
STAMPEDE low
volume
0.64
(0.42, 0.97)
0.034
High
OS (HR)
p value
LATTITUDE high risk
0.62
(0.51, 0.76)
<0.001
STAMPEDE high risk
0.54
(0.41, 0.74)
<0.001
STAMPEDE high
volume
0.60
(0.46, 0.78)
<0.001
Low
SOC before ESMO 2018 SOC after ESMO 2018
High risk
de novo
ADT + AA
ADT + DOC
ADT + AA
ADT + DOC
Low risk
de novo
(oligo M1)
Debated ADT alone or ADT
+ DOC
ADT + AA
(+ RT of the primary?)
Retrospective analysis of M1 STAMPEDE data according to
high/low risk stratification from LATITUDE and CHAARTED:
OS
Overall
OS (HR)
p value
STAMPEDE M1 cohort
0.61
(0.49, 0.79)
<0.001
Low
OS (HR)
p value
STAMPEDE low risk
0.66
(0.44, 0.98)
0.041
STAMPEDE low
volume
0.64
(0.42, 0.97)
0.034
High
OS (HR)
p value
LATTITUDE high risk
0.62
(0.51, 0.76)
<0.001
STAMPEDE high risk
0.54
(0.41, 0.74)
<0.001
STAMPEDE high
volume
0.60
(0.46, 0.78)
<0.001
Low
SOC before ESMO 2018 SOC after ESMO 2018
High risk
de novo
ADT + AA
ADT + DOC
ADT + AA
ADT + DOC
Low risk
de novo
(oligo M1)
+ DOC
ADT + AA
(+ RT of the primary?)
Hoyle AP et al. Ann Oncol 2018;29(Suppl