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Pharmacological inhibition of BTK (ibrutinib) in PDAC can reactivate adaptive
immune responses.
Gunderson et al, Cancer discov 2016
Stromal –associated
fibtroblast recruits
B regs
(produces TP),
may be inhibited by
BTK inhibitors, such
ibrutinib
RESOLVE: 1st line mPC
Gem-Abx-Ibrutinib vs Gem-Abx-Plcb