13 / 63
BRCA mutations and platinum sensitivity in PC
• 5-7 % of PC
à
BRCA-2 mutations
1
.
• Defects in BRCA-1-2, PALB-B2, FANC
à
Increase sensibility to
platinum
2
.
1 -Goggins, Cancer Res 1996, 2- Golan, Br. J Cancer 2014.
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13 / 63
13 / 63
BRCA mutations and platinum sensitivity in PC
• 5-7 % of PC
à
BRCA-2 mutations
1
.
• Defects in BRCA-1-2, PALB-B2, FANC
à
Increase sensibility to
platinum
2
.
1 -Goggins, Cancer Res 1996, 2- Golan, Br. J Cancer 2014.