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ES-ABR140097
• The IGF1R axis has been shown to be a key signalling pathway in
the growth and proliferation of malignant cells including PC
•
Ganitumab
is an anti-IGF1R monoclonal antibody initially
developed in patients with advanced pancreatic cancer with hints of
activity in a RP2 study
– Two phase III studies in patients with locally advanced and metastatic
disease were stopped early due to futility in the interim analysis.
•
MM-141
is an IGF-1R and ErbB3 directed antibody.
Insulin-like Growth Factor Receptor (IGF1R) in PC
Kindler HL et al. Ann Oncol 2012
Rand F II CARRIE
(NCT02399137)
88 Pts
mPC with Hight IGF-1
(serum)
Gem-Abx-MM-141
Gem-Abx-Pcb
Primary endpoint: PFS