34 / 40
•
Preclinical studies demonstrated
that HR can be suppressed by
hypoxia through downregulation
of HR repair proteins such as
BRCA1
and
RAD51
•
Further
studies
showed
sensitivity to PARP inhibitors
enhanced under
hypoxia
condition.
•
PARP inhibitors and anti-
angiogenics may have synergistic
effects
1. Bindra RS et al.
Cancer Res
. 2005; 2. Bindra RS et al.
Mol Cell Biol.
2004
3. Chan N.
Clin Cancer Res.
2010; 4. Hegan DC et al.
Proc Natl Acad Sci U S A.
2010
HR 0.42(
95% CI 0.23–0.76), p=0.005
Liu JF et al.
Eur J Cancer.
2013
Liu JF et al.
Lancet Oncol.
2014
Combination of PARPi and anti-angiogenic agent