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MOLECULAR BIOLOGY

Mafficini A & Scarpa A, et al. Journal of Endocrinology (2018) 236, R161–R167

Scarpa A, et al. Nature 2017; 543: 65

22%

7%

4%

GI NET:

- LOH cr. 18: 60-90%

- Low Mutational rate

- CDKN1B 8%

- Alterations in DNA methylation

41%

Pancreatic NET

1%

6%

10%

2%

2%

2%

3%

5%