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Quality of Life and survival in NSCLC: Impact of early

palliative intervention (at the start of chemotherapy)

Temel

et al. NEJM

2010

-5.0

-2.5

0

5.0

7.5

Standard care

FACT-L

Mean change

2.5

Early palliative

care

0

10

20

40

50

HADS-D

12-week outcomes of

assessments of mood

Patients with

mood symptoms (%)

30

HADS-A PHQ-9

Standard care

Early palliative care

0

20

40

80

100

0

Patients surviving (%)

60

10

20

30

40

Months

Standard care

Early palliative care

1:1 Randomization

N = 151

Initial chemotherapy

Survival:

11.6 vs 8.9 months

p

=0.02