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Step 2: biological activity

F(ab’)2-related

Fc-F(ab’)2-related

Fc-related

In Vitro TNFα Neutralization

Suppression of T Cell Proliferation by

Induced Regulatory Macrophages in MLR

Assay

C1q Binding Affinity

TNFα Binding Affinity (ELISA)

Quantitation of Induced Regulatory

Macrophages by FACS Analysis

Binding to Fc Receptors

FcγRIIIa (V Type) / FcγRIIIa (F Type),

FcγRIIIb,

FcγRIIa, FcγRIIb

FcγRI

FcRn

Cell Based Binding Affinity

Induced Regulatory Macrophage-

mediated Wound Healing

Ex Vivo Binding to NK Cells

1% BSA

50% Serum

Apoptosis (FACS) by Reverse

Signaling

CDC

Inhibition of Cytokine Release by

Reverse Signaling

ADCC in NK, PBMCs & WB

NK Cells

PBMCs

Whole Blood

Suppression of Cytokine Secretion

in Caco-2 Cells by Blocking sTNFα

ADCC using LPS-stimulated Monocytes

as Target Cells.

Expression Level of tmTNFα on

Monocyte/Macrophages from IBD

Patients