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expression between primary
and metastasis
Percentage of PD-L1–high in metastatic tumors
Percentage of PD-L1–high in primary tumors
0
10
20
30
40
50
60
70
0
10
20
30
40
50
60
P
= 1
¥
10
-
5
r
= 0.84
Bladder
Head−neck
Lung, adenocarcinoma
Lung, squamous
Breast,
luminal A
Ovary, serous
CRC−MSI
Gastric
Uterine
Melanoma
Breast, HER2
+
Breast, luminal B
Breast,TN
CRC
Liver
Pancreas, adenocarcinoma
Prostate
RCC
Smoking
HRD
MSI
UV
Other
Figure 4.
Correlation of PD-L1
–
high prevalence in pr
metastatic tumors across different cancer
Merck
–
Mof
fi
tt TCC (
P
¼
1
"
10
–
5
). CRC, colo
HRD, homologous recombination de
fi
cien
microsatellite instability
–
high; TCC, Total
TN, triple negative; UV, ultraviolet radiatio
Ayers et al.
Published OnlineFirst November 15, 2018; DOI: 10.1158/1078-0432.CCR-18-1316
Ayers, M et al. Clin Cancer Res 2018