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AR gain is associated with an adverse

outcome with long follow-up (Median

FU 37 m)

PSA-PFS

Radiographic-PFS

Overall Survival

HR 3.84 (95%CI: 1.77- 8.31); P= <0.001

HR: 13.60 (95%CI: 5.82-31.79); P<0.0001

HR:6.36 (95%CI: 3.04-13.31); P<0.0001