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Where can we use it? Potential algorithm

Molina A, et al. Eur J Cancer 2018

Good risk

Intermediate or Poor

risk

First Line

Options

Sunitinib

Pazopanib

Nivolumab + Ipilimumab

Cabozantinib

Second Line

Post-TKI

Nivolumab

Cabozantinib

Axitinib

Post-IO

Any TKi