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NTRK Gene Fusions
•
Pediatric tumor types in which NTRK gene fusions occur at
high frequency include
infantile fibrosarcoma, congenital
infantile fibrosarcoma, congenital mesoblastic nephroma
,
•
Other pediatric tumor types at moderately high frequencies,
including non-rhabdomyosarcoma soft tissue sarcoma,
childhood high grade glioma, pediatric papillary thyroid
cancer, and spitzoid neoplasms
•
Rare cancers that may occur in both adults and children which
have a high frequency of NTRK gene fusions include mammary
analogue
secretory carcinoma of the salivary gland and
secretory carcinoma of the breast
.
•
Common tumours (colorectal, NSCLC..)