46 / 48
1L
Crizotinib
erapy
2L
2
nd
generation ALK TKI
PD
PD
Lorlatinib
Ceritinib or
Lorlatinib
Crizotinib
Alectinib or
Lorlatinib
G1202R
I1171
F1174
L1198F
compound
3L
ALK-based
combo
WT
Genotyping for tailoring selection of Third-Line ALK Targeted
Strategies
REBIOPSY
1L
2
nd
generation ALK TKI
PD
No Alk mut
No MET amp