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Lung cancer

Pushing the boundaries – what have we achieved?

18

2000

1995

2010

2005

Median OS (months)

Scagliotti

Gatzemeier

Scagliotti

Giaccone

AVAiL

12

Schiller

Alberola

PARAMOUNT

ATLAS

E4599

AVAPERL

POINTBREAK

Non-PD after 4

cycles

All-comers

24

Anti-PD-1/L1

1L

EGFR

&

ALK

Mut+

Maintenance trials

1L trials

Recruitment

EURTAC

6

Pirker

2015

Anti-PD1

second-line

30

Anti-PD1/L1

> 3 years