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Lung cancer
Pushing the boundaries – what have we achieved?
18
2000
1995
2010
2005
Median OS (months)
Scagliotti
Gatzemeier
Scagliotti
Giaccone
AVAiL
12
Schiller
Alberola
PARAMOUNT
ATLAS
E4599
AVAPERL
POINTBREAK
Non-PD after 4
cycles
All-comers
IPASS
First-SIGNAL
NEJSG 002
24
Anti-PD-1/L1
1L
EGFR
&
ALK
Mut+
Maintenance trials
1L trials
Recruitment
EURTAC
OPTIMAL
6
EGFR & ALK
Mut+
Pirker
2015
Anti-PD1
second-line
30