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R/M treatment evolution in SCCHN.

The 80s

The 70s

The 90s

2

Last decade

The 2000

Palliative RT

MonoCT:

Bleomicine

Cisplatin

Methotrexate

PoliCT:

PF

PT

Taxol

Taxotere

PoliCT+Cetuximab:

EXTREME

ERBITAX

Checkmate 141

Keynote 040

2016 2017 2018

Keynote 048

Immunotherapy age

Cetuximab age

CT age

Only locally age

2019

Eagle