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Preoperative therapy is recommended for patients
who meet any of the following criteria:
1. Radiographic findings suspicious but not diagnostic for extrapancreatic
disease,
2. Performance status or comorbidity profile not currently appropriate (but
potentially reversible) for a major abdominal operation,
3. A radiographic interface between the primary tumor and the mesenteric
vasculature on cross-sectional imaging that does not meet appropriate
criteria for primary resection.
4. A CA 19-9 level (in the absence of jaundice) suggestive of disseminated
disease
ASCO Guidelines 2016
Be aware of the follow up visits periods!