18 / 38
Degradation of nal-IRI releases irinotecan which subsequently
is activated by CES present in the macrophage
van der Bol JM, et al. J Clin Oncol 2007;25:2719; Kalra AV, et al. Cancer Res 2014;74:7003;74:7003; Kawato Y,
et al. Cancer Res 1991,51:4187.