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Mismatch-repair deficiency predicts response of solid tumours to PD-1 blockade
1
N 86 patients with 12 tumor types MSI-H; Pembrolizumab
1.- Le et al, Science 2017
1% of pts with PC are MSH-H
2
How we can identify this patients?
KRAS WT?
Different hystological subtype?
2.- Humphris et al, Gastroenterology 2017