40 / 63
Ongoing trials modulating the stroma
• The stroma can block the penetration of
chemotherapeutic agents and facilitate
immune escape.
•
FAK
is a tyrosine kinase expressed in PDAC
cells and stroma that produces stromal
fibrosis.
Agent
Target Combined with Phase N
NCT
Defactinib FAK Pembrolizumab I/IIA 59* NCT02758587
VS-4718
FAK
Gem/nab
I
13 NCT02651727
Defactinib FAK Gem + pembro
I
50* NCT02546531
Jiang H, et al.
Nature Med.
2016
* Includes other cancers also