21 / 63
PSCA
(prostate stem cell antigen)
196
pts
Metastatic Panc Cancer
GS-1C4D4-Gem
Gem
1º endpoint: 6 m OS 60.9 %
p 0.03
40.4 %
median OS 7.6 m 5.5 m
RR 21.6 % 13.1 %
Rand. P. II with GS-1C4D4
(anti-PSCA mAb; Agensys/Astellas)
1
1.- Wolpin BM et al. Ann Oncol 2013
P I with BPX-601
(anti PSCA CAR-T)
(NCT02744287)
Ongoing
à
Planned 33
pts with mPC