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BRCA1m are strongly associated with TNBC and BRCA2m
with HR+/HER2- breast cancer
60-80%
of tumours in women carrying a
BRCA1
mutation have a triple
negative phenotype
>75%
of breast cancers among women with
BRCA2
mutations can be
classified as LA, LB
The majority of breast cancers in
individuals harbouring a germline
BRCA2 mutation are HR+/HER2-
Triple negative breast cancer is the
predominant subtype in individuals
with a germline
BRCA1
mutation
Robertson L . BJC 2012
Atchley DP. JCO 2008
Mavaddat N. Cancer Epidemiol Biomarkers Prev 2012