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BIOMARKER DATA SETS
Baseline tumor
tissue samples
Sample quality QC
DNA/RNA extraction
DNA/RNA
Targeted sequencing (570 genes)
n = 368 (42%)
Gene expression profiling (GEP)
NanoString customized panel (800
genes)
n = 507 (58%)
Paired DNA-RNA results
n = 301 (35%)
Library construction,
DNA-seq, filtering,
QC
NanoString
filtering, QC
Lymph node = 60%
Primary tumor = 35%
Can biomarkers predict clinical outcome and/or treatment benefit from adjuvant
targeted therapy?
PRESENTED BY GV LONG AT ESMO 2018
QC, quality control; seq, sequencing.