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Personal confilcts of interest

_ Scientific Consultancy Role (speaker

and advisory role) and travel grant:

IPSEN, Novartis, Roche, BMS,

Pfizer, Sanofi, Janssen, Astellas, Astrazeneca.

Participation in Clinical trials

:

Roche, BMS, MSD, Pfizer, Novartis,

IPSEN, Astrazeneca-Medimmune, Janssen, Eisai.

Research support

:

Roche.

DISCLOSURES