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• Preplanned subgroup analysis indicated improved OS benefit with

increasing HER2 expression by IHC

• Exploratory analysis of IHC 2+/FISH+ and IHC 3+ cohort demonstrated a

4-mo increase in OS with trastuzumab

• HR: 0.65 (95% CI: 0.51-0.83)

Bang YJ, et al. Lancet. 2010;376:687-697.