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Stage III
ü
At diagnosis, more than a third of NSCLC patients have Stage III disease.
ü
Multimodality treatment
is necessary in this group of patients:
ü
Surgical resection or radiotherapy alone are associated
with poor
outcome (10% 5-year survival)
ü
Micrometastatic disease
is often present when N2 nodes are involved;
the majority of patients eventually relapse and
two-thirds
of the relapses
are systemic