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Germline DNA-repair gene mutations in men with metastatic prostate cancer
•
Analysis of 20 DNA-repair genes in men with mPC
(N = 692)
•
82 men (
11.8%)
had total of 84 germline
mutations across 16 DNA-repair genes
•
DNA-repair gene mutations less common in
locally advanced prostate cancer
(4.6%)
•
Unclear association with family history!
•
Family history as a driver would have missed 37% of
patients with important mutations.
•
Other genes of intertest are missed by NCCN guidelines
Pritchard CC, et al. N Engl J Med. 2016;375:443-453; Nicolosi PLW, et al. ASCO 2017. Abstract 5009