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Tki are active but…Not all are good news
MOTZER
TRIAL
COMPARZ
TRIAL
CHECK-MATE
214
(Int/por PDL1+)
CABOSUN JAVELIN 101
(All/PDL1+)
Immotion 151
(All/PDL1+)
SUN INF SUN PAZ Niv/Ipi
SUN CABO SUN AX+BV SU AT+BV SU
ORR, %
31
6
25 31 58 22 20
9
55 26 43 35
Complete
Response
0
0
1
1
16
1
1
0
4
2
9
4
Partial
Response
31
6
24 31 42 21 20
9
51 23 34 30
Stable Disease
48 49 44 39 19 40 54 38 27 43 32 35
PROGRESSION 21 45 19 17 14 25 18 29 11 22 19 21
Not evaluable
NR NR 12 13
9
13
8
23
4
7
7
10