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PFS AND OS, ENTRECTINIB

Data cut-off date: May 31 2018, ROS1-inihibitor-naïve patients with

ROS1+

NSCLC (integrated analysis population)

100

0

80

60

40

20

0

6

12

18

24

30

36

Time (months)

28

37

8

6

3

53

15

32

6

5

1

43

1

Total

Censored

Median + 95% CI

Total (N=53): 19.0 (12.2–36.6)

Median PFS 19.0 months

(95% CI 12.2, 36.6)

42

Total

No. at risk

PFS by BICR (%)

PFS,

ROS1+

NSCLC

12-month event-free

probability: 0.65