4 / 32
Drug-related AEs (>10%)
†
Plus 1 case of grade 4 diarrhea
‡
Plus 1 case of grade 4 increased ALT
ALT, alanine aminotransferase; AST, aspartate aminotransferase
AE category, %
Afatinib (n=160)
Gefitinib (n=159)
All
Grade 3
All
Grade 3
Diarrhea
90.0
11.9
†
61.0
1.3
Rash/acne*
88.8
9.4
81.1
3.1
Stomatitis*
64.4
4.4
23.9
-
Paronychia*
55.6
1.9
17.0
0.6
Dry skin
32.5
-
37.1
-
Pruritus
23.1
-
22.6
-
Fatigue*
20.6
5.6
14.5
-
Decreased appetite
16.3
0.6
11.9
-
Nausea
16.3
1.3
13.8
-
Alopecia
10.6
-
15.1
-
Vomiting
10.6
-
3.8
0.6
ALT increased
9.4
-
23.9
7.5
‡
AST increased
6.3
-
20.8
2.5
*Grouped terms of AEs