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Homologous Recombination Deficiency (HRD)
How to identify it?
•
DNA-based measures of genomic instability
reflecting underlying
tumor HRD:
o
Loss of heterozygosity (LOH)
o
Telomeric allelic imbalance (TAI)
o
Large-scale state transitions (LST)
Test LOH
Foundation Medicine
Test MyChoice®
Myriad
LOH
LOH, LST y TAI
Rucaparib
Niraparib