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Un poco de historia...
1962 – Sutow & Pinkel – Cyclophosphamide- ¾ response
1966 – Jenkin – N2 mustard – 3/3 response
1968 – Hustu – comb – V+C & RT- sustained resp-5 pt
1976 – Jaffee- sup survival – VAC vs Single agent
1976 – Rosen MSKCC- RT+ VACD comb- long term survival 12 pts