BRAF V600E
BRAF non-V600
MSI
DDR
POLE mut
HER2 ampl
MET ampl
Gene
fusion
RAS mut +/-
PIK3CA/PTEN mut
PIK3CA/PTEN mut
Wild-type
anti-EGFR therapies
BRAF inh + anti-EGFR + MEK inh
anti-PD1/L1
double anti-HER2
Kinase inh
45%
8%
26%
8%
2%
2%
1%
1%
2%
2%
2%
MET inh
To be defined
To be defined
To be defined
Genomic CRC classification