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BRAF V600E

BRAF non-V600

MSI

DDR

POLE mut

HER2 ampl

MET ampl

Gene

fusion

RAS mut +/-

PIK3CA/PTEN mut

PIK3CA/PTEN mut

Wild-type

anti-EGFR therapies

BRAF inh + anti-EGFR + MEK inh

anti-PD1/L1

double anti-HER2

Kinase inh

45%

8%

26%

8%

2%

2%

1%

1%

2%

2%

2%

MET inh

To be defined

To be defined

To be defined

Genomic CRC classification